human placental extract ameliorates structural lung changes iinduced by amiodarone in rats

Authors

fatemeh samiei 1. department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, fars, iran

akram jamshidzadeh 2. pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, fars, iran

ali noorafshan 3. histomorphometry and stereology research center, shiraz university of medical sciences, shiraz, fars, iran

amir ghaderi 4. department of pharmacology and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran

abstract

amiodarone is used in treatment of cardiac arrhythmias. therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. human placenta extract (hpe) contains a variety of bio-active substances. thus, the present study aimed to quantitatively evaluate the protective effects of hpe on the structural lung changes induced by amiodarone using stereological methods. sprague-dawley male rats were divided into four groups. the first, second, and third groups received no treatment, amiodarone (100 mg/kg, i.p.), and hpe (500µl/kg, i.p.), respectively. the fourth group was treated with amiodarone+hpe. the animals' lungs were removed after 10 days. the lung volume was estimated using the cavalieri principle on the embedded and cut tissue and corrected for shrinkage. the volume density of the parenchyma, alveolar space, and septa were estimated using point-counting method. the surface area of the alveoli, the volume-weighted means alveoli volume, and mean septum thickness were also estimated in all groups. the total volume and thickness of the alveolar septum were increased by 40% and 28%, respectively. however, the total volume of the alveolar space was decreased by 31% in the amiodarone treated-rats. the mean alveolar volume was decreased by 64% on the average in the amiodarone treated group. yet, these changes were not detected in the amiodarone+hpe group. moreover, rbc accumulation in the alveolar space and septa was ameliorated after hpe treatment. hpe can protect the lung tissue from the structural changes induced by amiodarone.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats

Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

full text

Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats

Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

full text

Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats

Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

full text

Human placental extract stimulates liver regeneration in rats.

The effect of human placental extract (HPE) on liver regeneration in rats was investigated. After intravenous administration of HPE to a-naphthylisothiocyanate (ANIT)-intoxicated rats, the labeling index in hepatocytes was significantly increased to a level 16.5 times higher than that of the control. A 1/500 dilution of HPE directly stimulated DNA synthesis of the hepatocytes in primary culture...

full text

Black ginseng extract ameliorates hypercholesterolemia in rats.

BACKGROUND Ginseng (Panax ginseng Meyer) is a well-characterized medicinal herb listed in the classic oriental herbal dictionary as "Shin-nong-bon-cho-kyung." Ginseng has diverse pharmacologic and therapeutic properties. Black ginseng (BG, Ginseng Radix nigra) is produced by repeatedly steaming fresh ginseng nine times. Studies of BG have shown that prolonged heat treatment enhances the antioxi...

full text

Hydro-Ethanolic Extract of Portulaca Oleracea Ameliorates Total and Differential WBC, Lung Pathology and Oxidative Biomarkers in Asthmatic Rats

Objective: The effects of Portulaca oleracea (P. oleracea; PO) on total and differential WBC count, and oxidant/antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) as well as on lung pathology in asthmatic rats were examined. Methods and Methods: Rats were randomly divided into; control group (C), asthma group, asthma groups treated with either P. oleracea (rats that received P...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۱۵، شماره Special Issue، صفحات ۷۵-۸۲

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023